Effects of rhBMP-2 with various carriers on maxillofacial bone regeneration through computed tomography evaluation
서자인, 김은영, 조우민, 이정근, 송승일,
소속 상세정보
서자인 ( Seo Ja-In ) -
김은영 ( Kim Eun-Young ) -
조우민 ( Jo Woo-Min ) -
이정근 ( Lee Jeong-Keun ) -
송승일 ( Song Seung-Il ) -
Abstract
Background : rhBMP-2 is regarded as the most potent osteoinductive growth factor, and it has been used in the oral cavity with different carriers. The purpose of this study is to evaluate the bone-regenerative effect of rhBMP-2 delivered with different carrier systems through three-dimensional cone beam computed tomography analysis.
Method : A total of 112 patients underwent oral surgery with rhBMP-2 application (Group 1, n?=?53) or without rhBMP-2 application (Group 2, n?=?59). Group 1 was divided into 3 groups according to carriers, rhBMP-2 with allograft (Group 1?1, n?=?34), rhBMP-2 with xenograft (Group 1?2, n?=?5), and rhBMP-2 with absorbable collagen sponge (Group 1?3, n?=?14). Cone beam computed tomography scans were taken before surgery (T0) 6 months after surgery (T1). The volume of defects was measured through the three-dimensional image analysis tool.
Results : The average bone regeneration rate of Group 1 was significantly greater than that of Group 2. Within Group 1, the group that used allograft as a carrier (Group 1?1) showed significantly higher bone regeneration rates than the group that used absorbable collagen sponge as a carrier (Group 1?3).
Conclusion : The use of rhBMP-2 after oral surgery results in a superior bone regeneration rate compared to not using rhBMP-2, and its efficacy depends on the carriers it is used with. Allograft affects bone regeneration more than absorbable collagen sponge when it is carried with rhBMP-2. Therefore, the appropriate use of rhBMP-2 with suitable bone grafting materials is useful for promoting postoperative bone regeneration in oral surgery.
키워드
Recombinant human bone morphogenetic protein 2; Bone regeneration; Cone beam computed tomography
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